Sam Rockwell Wolf (voice) Marc Maron Snake (voice) Craig Robinson Shark (voice) Anthony Ramos Piranha (voice) Awkwafina Tarantula (voice) Danielle Brooks Kitty Kat (voice) Maria Bakalova Pigtail Petrova (voice) Natasha Lyonne Doom aka Susan (voice) Zazie Beetz Diane Foxington (voice) Richard Ayoade Professor Marmalade (voice) Alex Borstein Commissioner Misty Luggins (voice) Lilly Singh Tiffany Fluffit (voice) Omid Djalili Mr. Soliman (voice) Colin Jost Mr. Moon (voice) Jaime Camil Handsome Jorge Garcia (voice) Jorge R. Gutierrez Lucha Spectator (voice) Joey Naber Servant / Cairo Cop 1 (voice) Monia Ayachi Cairo Security Guard 1 (voice) Shelby Young Interviewer 2 / Bride (voice)